The first commercial cultivation of grapefruit occurred less than 200 years ago. Interaction of grapefruit with certain commonly used drugs has been reported we examine the mode of interactions and address this concern. Because grapefruit is valued as a highly nutritious fruit, we will discuss the significant health benefits associated with it. We review the progress and fluctuations in production and market aspects. This review discusses grapefruit’s evolution from its identification in Barbados to its development as an important agricultural commodity. However, taxonomists now characterize grapefruit as a set of cultivars rather than a species it is classified as C. Earlier, grapefruit was considered an apomictically stabilized hybrid species ( Kumamoto et al., 1987). Based on chemotaxonomy ( Scora et al., 1982) and molecular data ( Wu et al., 2018), it is presumed that an accidental hybridization produced the interspecific hybrid of a pummelo and sweet orange, now classified as grapefruit. Browne (1756) also reported a tree bearing the “forbidden fruit” and associated it with ‘Shaddock’ pummelo ( Citrus maxima), describing it as a “smaller shaddock.” Macfadyen (1830) classified the “forbidden fruit” reported by both Browne and Hughes as Citrus × paradisi also known as “barbados grapefruit.” Bowman and Gmitter (1990) and Gmitter (1995) further confirmed the association of the now extinct “forbidden fruit” with ‘Shaddock’ pummelo and the present-day grapefruit. Hughes (1750) reported a tree bearing the “forbidden fruit” in Barbados, but today’s grapefruit is not a direct descendent of this tree. The origin of grapefruit in the Caribbean islands is shrouded in mystery and confusion ( Kumamoto et al., 1987).

Citron ( Citrus medica), considered a progenitor species of cultivated citrus ( Raveh et al., 2020), dates back to 4000 BCE ( Webber, 1967).

Most cultivated citrus originated in Southeast Asia before 2000 BCE. Grapefruit is unique among citrus ( Citrus sp.) fruit due to its distinctive flavor, health benefits, and recent Caribbean islands’ origin less than 300 years ago ( Scora, 1975). Grapefruit ( Citrus × aurantium) belongs to the family Rutaceae, subfamily Aurantioideae. Keywords: biotechnology drug interaction mutation breeding natural mutation protoplast somatic hybrids

Benefit of pink grapefruit